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- CreatorDavid CraneMarta KauffmanStarsJennifer AnistonCourteney CoxLisa KudrowFollows the personal and professional lives of six twenty to thirty year-old friends living in the Manhattan borough of New York City.
- CreatorChuck LorreBill PradyStarsJohnny GaleckiJim ParsonsKaley CuocoAspiring film actress Penny moves into a Pasadena apartment across the hall from brilliant, but socially awkward, physicists Sheldon Cooper and Leonard Hofstadter and shows them how little they know about life outside of the lab.
- CreatorCarter BaysCraig ThomasStarsJosh RadnorJason SegelCobie SmuldersA father recounts to his children - through a series of flashbacks - the journey he and his four best friends took leading up to him meeting their mother.
- CreatorElizabeth MeriwetherStarsZooey DeschanelJake JohnsonMax GreenfieldAfter a bad break-up, Jess, an offbeat young woman, moves into an apartment loft with three single men. Although they find her behavior very unusual, the men support her - most of the time.
- CreatorTom HertzStarsPatrick WarburtonMegyn PriceOliver HudsonTwo couples and their single friend, all at different stages in their relationships, deal with the complications of dating, commitment, and marriage.
- CreatorJustin AdlerStarsColin HanksBetsy BrandtThomas SadoskiA family comedy told through the separate stories of different family members.
- CreatorSteven LevitanChristopher LloydStarsEd O'NeillSofía VergaraJulie BowenThree different, but related, families face trials and tribulations in their own uniquely comedic ways.
- CreatorMichael SchurStarsKristen BellWilliam Jackson HarperJameela JamilFour people and their otherworldly frienemy struggle in the afterlife to define what it means to be good.
- CreatorRobert CarlockTina FeyStarsEllie KemperJane KrakowskiTituss BurgessA woman is rescued from a doomsday cult and starts life over again in New York City.
- CreatorKenya BarrisStarsAnthony AndersonTracee Ellis RossMarcus ScribnerA family man struggles to gain a sense of cultural identity while raising his kids in a predominantly white, upper-middle-class neighborhood.
- CreatorKenya BarrisLarry WilmoreStarsTrevor JacksonYara ShahidiDiggy SimmonsA spinoff of ABC's "Black-ish," Zoey Johnson is off to college and must live outside the nest, dealing with drugs, sex, and relationships along the way.
- CreatorDavid AngellPeter CaseyDavid LeeStarsKelsey GrammerJane LeevesDavid Hyde PierceDr. Frasier Crane moves back to his hometown of Seattle, where he lives with his father and works as a radio psychiatrist.
- CreatorJeff FranklinStarsBob SagetJohn StamosDave CoulierA widowed sportscaster raises his three daughters with assistance from his rock and roll brother-in-law and madcap best friend.
- CreatorGreg DanielsRicky GervaisStephen MerchantStarsSteve CarellJenna FischerJohn KrasinskiA mockumentary on a group of typical office workers, where the workday consists of ego clashes, inappropriate behavior, tedium and romance.
- CreatorLarry DavidJerry SeinfeldStarsJerry SeinfeldJulia Louis-DreyfusMichael RichardsThe continuing misadventures of neurotic New York City stand-up comedian Jerry Seinfeld and his equally neurotic New York City friends.
- CreatorAndy BorowitzSusan BorowitzStarsWill SmithJames AveryAlfonso RibeiroA streetwise, poor young man from Philadelphia is sent by his mother to live with his aunt, uncle and cousins in their Bel-Air mansion.
- CreatorBill LawrenceStarsZach BraffDonald FaisonSarah ChalkeIn the unreal world of Sacred Heart Hospital, intern John "J.D." Dorian learns the ways of medicine, friendship and life.
- CreatorSusan HarrisStarsBea ArthurBetty WhiteRue McClanahanFour previously married women live together in Miami, sharing their various experiences together and enjoying themselves despite hard times.
- CreatorAdam F. GoldbergStarsWendi McLendon-CoveySean GiambroneTroy GentileThis ABC show takes place in Jenkintown, Pennsylvania in the 1980s and follows the lives of a family named The Goldbergs.
- CreatorScott SilveriStarsMinnie DriverJohn Ross BowieCedric YarbroughThe family of a special-needs teen is good at dealing with the challenges he faces--and excellent at creating new ones.
- CreatorMark BrazillBonnie TurnerTerry TurnerStarsTopher GraceLaura PreponMila KunisA comedy revolving around a group of teenage friends, their mishaps, and their coming of age, set in 1970s Wisconsin.
- CreatorPaul FeigStarsLinda CardelliniJohn Francis DaleyJames FrancoA high school mathlete starts hanging out with a group of burnouts while her younger brother navigates his freshman year.
- CreatorRon LeavittMichael G. MoyeStarsEd O'NeillChristina ApplegateKatey SagalAl is the quintessential working class dad. Peggy, his wife, always wants more from him. With their children, they go through the highs and lows of ordinary life.
- CreatorPhil RosenthalStarsRay RomanoPatricia HeatonBrad GarrettThe comical everyday life of whiny Mama's-boy sports columnist Ray Barone and his dysfunctional family: his long-suffering hard-working wife Debra, smothering mother Marie, coarse father Frank, and jealous policeman brother Robert.
- CreatorLinwood BoomerMichael GloubermanGary MurphyStarsFrankie MunizBryan CranstonJustin BerfieldA gifted young teen tries to survive life with his dimwitted, dysfunctional family.