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- CreatorAdam ReedStarsH. Jon BenjaminJudy GreerAmber NashCovert black ops and espionage take a back seat to zany personalities and relationships between secret agents and drones.
- CreatorGreg DanielsMichael SchurStarsAmy PoehlerJim O'HeirNick OffermanThe absurd antics of an Indiana town's public officials as they pursue sundry projects to make their city a better place.
- CreatorDan HarmonJustin RoilandStarsChris ParnellSpencer GrammerSarah ChalkeThe fractured domestic lives of a nihilistic mad scientist and his anxious grandson are further complicated by their inter-dimensional misadventures.
- CreatorMitchell HurwitzStarsJason BatemanMichael CeraPortia de RossiLevel-headed son Michael Bluth takes over family affairs after his father is imprisoned. But the rest of his spoiled, dysfunctional family are making his job unbearable.
- CreatorDan GoorMichael SchurStarsAndy SambergStephanie BeatrizTerry CrewsComedy series following the exploits of Det. Jake Peralta and his diverse, lovable colleagues as they police the NYPD's 99th Precinct.
- CreatorBill LawrenceStarsZach BraffDonald FaisonSarah ChalkeIn the unreal world of Sacred Heart Hospital, intern John "J.D." Dorian learns the ways of medicine, friendship and life.
- CreatorChuck LorreBill PradyStarsJohnny GaleckiJim ParsonsKaley CuocoAspiring film actress Penny moves into a Pasadena apartment across the hall from brilliant, but socially awkward, physicists Sheldon Cooper and Leonard Hofstadter and shows them how little they know about life outside of the lab.
- CreatorAndy BorowitzSusan BorowitzStarsWill SmithJames AveryAlfonso RibeiroA streetwise, poor young man from Philadelphia is sent by his mother to live with his aunt, uncle and cousins in their Bel-Air mansion.
- CreatorBen BocqueletStarsD.G. MaloneyVincent AmorosiMaximillian PaulThe life of a twelve-year-old boy who happens to be a blue cat as he lives with his family and other strange creatures.
- CreatorIan BrennanBrad FalchukRyan MurphyStarsLea MicheleJane LynchMatthew MorrisonA group of ambitious misfits try to escape the harsh realities of high school by joining a glee club headed by a passionate Spanish teacher.
- CreatorDavid E. KelleyStarsJames SpaderWilliam ShatnerCandice BergenBoston Legal is a spin-off of the long-running David E. Kelley series The Practice (1997), following the exploits of former Practice character Alan Shore (James Spader) at the legal firm of Crane, Poole, and Schmidt.
- CreatorDarren StarStarsSarah Jessica ParkerKim CattrallKristin DavisFour female New Yorkers gossip about their sex lives (or lack thereof) and find new ways to deal with being a woman in the late 1990s.
- CreatorAlex HirschStarsJason RitterAlex HirschKristen SchaalTwin siblings Dipper and Mabel Pines spend the summer at their great-uncle's tourist trap in the enigmatic Gravity Falls, Oregon.
- CreatorRob LottersteinStarsMichael RapaportAnita BaroneKaylee DeFerParents struggle to raise their teens.
- CreatorClaudia LonowStarsJenna ElfmanJon FosterAshley Jensen37-year-old Billie breaks up with her boss at the newspaper and gets pregnant by 22-year-old Zack, who moves into her apartment. They both have their pals.
- CreatorDavid CraneMarta KauffmanStarsJennifer AnistonCourteney CoxLisa KudrowFollows the personal and professional lives of six twenty to thirty year-old friends living in the Manhattan borough of New York City.
- CreatorPaul FeigStarsLinda CardelliniJohn Francis DaleyJames FrancoA high school mathlete starts hanging out with a group of burnouts while her younger brother navigates his freshman year.
- CreatorJames L. BrooksMatt GroeningSam SimonStarsDan CastellanetaNancy CartwrightHarry ShearerThe satiric half-hour adventures of a working-class family in the misfit city of Springfield.
- CreatorTrey ParkerMatt StoneBrian GradenStarsTrey ParkerMatt StoneIsaac HayesFollows the misadventures of four irreverent grade-schoolers in the quiet, dysfunctional town of South Park, Colorado.
- CreatorDavid X. CohenMatt GroeningStarsBilly WestJohn DiMaggioKatey SagalPhilip J. Fry, a pizza delivery boy, is accidentally frozen in 1999 and thawed out on New Year's Eve 2999.
- StarsSimon BirdJames BuckleyBlake HarrisonFollows four friends and their antics during their final years of school.
- CreatorMark BrazillBonnie TurnerTerry TurnerStarsTopher GraceLaura PreponMila KunisA comedy revolving around a group of teenage friends, their mishaps, and their coming of age, set in 1970s Wisconsin.
- CreatorDan HarmonStarsJoel McHaleDanny PudiDonald GloverA suspended lawyer is forced to enroll in a community college with an eccentric staff and student body.
- CreatorJohn AltschulerMike JudgeDave KrinskyStarsThomas MiddleditchT.J. MillerJosh BrenerFollows the struggle of Richard Hendricks, a Silicon Valley engineer trying to build his own company called Pied Piper.
- CreatorVictor FrescoStarsJay HarringtonPortia de RossiAndrea AndersIn an amoral science-based company, a manager tries to keep control of his scientists while being pressured by his shrewd boss.