The SIN corporation tries to analyze Ryu's power "Satsui no Hado" to incorporate it into their mysterious BLECE project with M. Bison being the power behind SIN. It introduces a new system called Focus Attacks, as well as Ultra Moves.
14th century France, Amicia and her little brother Hugo are on the run from the Inquisition's soldiers and survive during their emotional journey unstoppable swarms of rats from the Black Plague.