Derek & Meredith
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- DirectorPeter HortonStarsEllen PompeoSandra OhKatherine HeiglThe first shift for new surgical interns Meredith, Cristina, Izzie, George, and Alex proves eventful and backbreaking.
- DirectorPeter HortonStarsEllen PompeoSandra OhKatherine HeiglA rape victim is admitted, who managed to hold onto part of her attacker; Izzie has difficulty with a patient who cannot speak English; Meredith becomes concerned about a sick baby.
- DirectorDarnell MartinStarsEllen PompeoSandra OhKatherine HeiglIzzie and George find out about Meredith and Derek, while Cristina makes a discovery of her own. George thinks an anesthesiologist is drinking on the job, and Meredith deals with a young girl who has had illegal surgery.
- DirectorWendey StanzlerStarsEllen PompeoSandra OhKatherine HeiglGeorge finally gets laid but gets syphilis. It's rampant among staff. Surgeon Webber is losing his sight. He wants Shepherd to operate secretly. A male patient has an ovary. A lifesaving autopsy's performed without consent.
- DirectorPeter HortonStarsEllen PompeoSandra OhKatherine HeiglMeredith, shattered by revelations, is forced to work with Addison, Joe collapses at the bar, Cristina has some pretty shattering news of her own, and Alex starts working on Izzie.
- DirectorAdam DavidsonStarsEllen PompeoSandra OhKatherine HeiglMeredith is horrified when her mother is admitted, and everyone is concerned when Cristina collapses in the operating room. Meanwhile, Addison is determined to save a very sick baby.
- DirectorMark TinkerStarsEllen PompeoSandra OhKatherine HeiglA storm rages, causing power outages and jamming the elevator, trapping George and Alex inside with a vulnerable patient. Meanwhile, Meredith and Derek arrange a religious ritual for a young woman, and Cristina deals with an unusual case.
- DirectorJeff MelmanStarsEllen PompeoSandra OhKatherine HeiglA train wreck brings in multiple casualties, leaving Meredith hanging for her answer. Meanwhile, Alex finds working without his mojo a disheartening experience, and Cristina searches high and low for a missing appendage.
- DirectorLesli Linka GlatterStarsEllen PompeoSandra OhKatherine HeiglFriends of Derek and Addison come from New York for a preventative surgery that causes discord among both couples. Meanwhile, George helps a man who has fallen from a roof, and Bailey delivers news to the Chief.
- DirectorDavid PaymerStarsEllen PompeoSandra OhKatherine HeiglThe nurses are striking, and George refuses to cross the picket line. The interns are surprised by Bailey's seemingly immature replacement, Izzie connects with a pregnant girl, and an elderly woman's plight pushes Meredith to the limit.
- DirectorPeter HortonStarsEllen PompeoSandra OhKatherine HeiglThe lives of everyone in the OR are threatened when a patient enters with a bomb inside him, and a young paramedic with her arm inside the cavity is the only thing keeping it from going off.
- DirectorPeter HortonStarsEllen PompeoSandra OhKatherine HeiglWhile the man with the bomb lodged in his chest remains in Burke's OR with Meredith's hand in the cavity, Bailey's injured husband remains in Derek's. Meanwhile, Bailey's distress puts her unborn baby at risk.
- DirectorDaniel MinahanStarsEllen PompeoSandra OhKatherine HeiglThe victims of a workplace shooting are admitted. Izzie puts her job on the line to ensure Denny gets a new heart, Callie makes an effort with Meredith, and Addison is suspicious of Derek.
- 2005– 1hTV-149.0 (2K)TV EpisodeDirectorRob CornStarsEllen PompeoSandra OhKatherine HeiglBurke is admitted as a patient, along with Richard's niece. Izzie and the others fight to keep Denny alive, while Alex tries to secure the donor heart for him.
- DirectorMark TinkerStarsEllen PompeoSandra OhKatherine HeiglRichard is determined to discover the guilty party, and punishes the interns by making them arrange a prom for his niece. Meanwhile, Callie presses George about his feelings, and Derek and Meredith have to make a decision about Doc.
- DirectorDaniel MinahanStarsEllen PompeoSandra OhKatherine HeiglEveryone reminisces about the past. Meanwhile, Izzie is emotionally devastated, with the others trying to help her, Adele gives Richard an ultimatum, and George and Derek are put in quarantine when an outbreak of the plague is suspected.
- DirectorDan LernerStarsEllen PompeoSandra OhKatherine HeiglMeredith becomes a patient, and Derek and Addison are equally angry at Richard for allowing Mark to join the staff. Meanwhile, Izzie receives a visit from Denny's father, and Burke is plagued by doubt over his ability to return to surgery.
- DirectorDaniel MinahanStarsEllen PompeoSandra OhKatherine HeiglDerek, George, Alex, Burke, Richard, Joe and Walter go on a camping trip. Meanwhile, Meredith assists Mark with gender reassignment surgery, Izzie avoids discussing her grief, Addison works with Callie, and Cristina feels Bailey's wrath.
- DirectorJeff MelmanStarsEllen PompeoSandra OhKatherine HeiglGeorge must deal with his family's presence when his father is admitted. Meanwhile, Burke's secret is almost out, Alex tries to get close to Izzie again, and Richard comes to a decision about his marriage.
- DirectorJulie Anne RobinsonStarsEllen PompeoSandra OhKatherine HeiglA traumatic car accident fills the ER. Cristina has a crisis of conscience about her deceptive teamwork with Burke, Izzie pushes the boundaries of her probation, and Callie tries to explain herself to George.
- DirectorJulie Anne RobinsonStarsEllen PompeoSandra OhKatherine HeiglA toxic patient wreaks havoc. Meanwhile, Bailey opens the free clinic, but the lack of patients makes Izzie question her investment. Meredith's mother is admitted again, and Cristina makes Burke wait for an answer.
- DirectorRob CornStarsEllen PompeoSandra OhKatherine HeiglThe interns each react differently to a mass-casualty incident. Meanwhile, George crosses the professional line with Callie, Cristina asks Burke to keep quiet about their engagement, and Richard dons a new hairstyle.
- DirectorRob CornStarsEllen PompeoSandra OhKatherine HeiglIzzie fights to save her patient's life, George searches for the son of his patient, and Alex has to contend with the relatives of victims. Meanwhile, Meredith is unconscious underwater, with Derek her only hope.
- DirectorAdam ArkinStarsEllen PompeoSandra OhKatherine HeiglAn unconscious Meredith interacts with some ghosts from her past while Richard, Burke and Bailey devise an unusual method of reviving her. A despondent Cristina leaves during her shift, and Derek speaks his mind to Meredith's mother.
- DirectorTom VericaStarsEllen PompeoSandra OhKatherine HeiglThe Chairman of Seattle Grace's board of directors is admitted, and the attendings vie for his favor, while the interns study for exams. Izzy and George are reminded of their infidelity, and Burke presses Cristina about wedding plans.