- At the Wimbledon Championships 2014, she defeated reigning Australian Open champion Li Na in the third round, in soon-to-be last professional match for world No. 2.
- At the Summer Olympics in Rio on August 13 she won her first ever Olympic medal, a bronze in the women's doubles playoff with her partner Lucie Safárová.
- On 2 March 2015, she achieved a career-high ranking of world No. 20. It was the first time in the Open Era that the world's top 20 featured four Czech women (also with Petra Kvitová at No. 4, Lucie Safárová at No. 11, and Karolína Plísková at No. 15).
- At Western & Southern Open in Cincinnati 2016, she came away with the women's doubles title with her new partner Sania Mirza while defeating Martina Hingis and CoCo Vandeweghe in the finals.
- Strýcová was a strong junior player, winning two Grand Slams in girls' singles: the 2002 Australian Open and then defending that title the following year. She also won three Grand Slam girls' doubles titles between 2001 and 2003.
- Strýcová announced her retirement on 4 May 2021, whilst leaving open the possibility of a final match at the 2022 Wimbledon Championships, or at a tournament in the Czech Republic.
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