Yomeddine probably means Judgement Day. Leprosy (known as Hansen's Disease) is curable; not inheritable; not transmitted once cured; 95% of the population has a natural immunity. The scaring & deformities make it so that many members of the last colony in Egypt, where this movie was made, prefer the security & comfort that it provides rather than leaving.
The story, using non-actors, follows our scarred Beshay & an orphaned 10 year old kind neighbor (appropriately nicknamed Obama), as they travel across Egypt by donkey cart; walking; by train; hitchhiking to locate Beshay's family. One moral in the movie is that what's important is our humanity & not material things (something a U.S. political leader has yet to learn).