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- Aspiring film actress Penny moves into a Pasadena apartment across the hall from brilliant, but socially awkward, physicists Sheldon Cooper and Leonard Hofstadter and shows them how little they know about life outside of the lab.
- Ira Steven Behr explores the legacy of Star Trek: Deep Space Nine (1993).
- The Dreadnought Dominion Project takes place at the end of the third season of Star Trek (TOS, produced from 1966-70). Dominion introduces a Federation Class Starship with a tri-nacelle configuration first introduced in the "Star Trek Starfleet Technical Manual," by Franz Joseph Designs (©1975 used with permission). This exciting new series chronicles the voyages of the U.S.S. Dominion NCC-2115 and her crew, commanded by Commodore Samuel Tobias Grissom. The mission is one of deep space exploration, visiting Earth colonies, patrolling the Romulan Neutral Zone, and first contact with new civilizations.
- A pair of socially awkward theoretical physicists meet their new neighbor Penny, who is their polar opposite.
- Police detective Marshak and his nameless, silent, new rookie partner, through whose eyes the show is seen, investigate the murder of a beautiful, seductive, unscrupulous, scheming and ambitious young blonde female news anchor.
- Penny is furious with Leonard and Sheldon when they sneak into her apartment and clean it while she is sleeping.
- Leonard gets upset when he discovers that Penny is seeing a new guy, so he tries to trick her into going on a date with him.
- Sheldon's mother is called to intervene when he delves into numerous obsessions after being fired for being disrespectful to his new boss.
- Leslie seduces Leonard, but afterwards tells him that she is only interested in a one-night stand.
- 2007–201921mTV-PG8.3 (5.3K)TV EpisodeThe guys are invited to Penny's Halloween party, where Leonard has yet another run-in with Penny's ex-boyfriend Kurt.
- Leonard lies to Penny so he and Sheldon can get out of watching her perform, but Sheldon believes that the lie has too many loose ends, so he comes up with a new, unnecessarily complex one to replace it.
- 2007–201922mTV-PG8.2 (4.9K)TV EpisodeWhen Sheldon gets sick, Leonard, Howard and Raj go AWOL, leaving a reluctant Penny to deal with him.
- Sheldon decides to give up his work and focus on other tasks when a 15-year-old prodigy joins the university, so the other guys come up with a plan to get rid of him.
- Sheldon becomes so intent on demonstrating his intellectual superiority over the other guys that they kick him off the Physics Bowl team and replace him with his nemesis, Leslie.
- When Raj's parents set him up on a blind date, he finds he can talk to women with the aid of alcohol.
- 2007–201920mTV-PG8.0 (4.8K)TV EpisodeLeonard and Sheldon's friendship is put to the test when Leonard wants to present a paper they co-authored at a physics convention, but Sheldon doesn't.
- 2007–201920mTV-PG8.0 (4.7K)TV EpisodePenny gets mad at the guys when their full scale model of a time machine causes her to miss work, which prompts Leonard to give up all of his nerd memorabilia.
- 2007–201922mTV-PG8.2 (5K)TV EpisodeLeonard, Howard and Raj fight over Sheldon's twin sister when she arrives in town. Raj takes part in a drug trial to suppress his selective mutism.
- When Penny learns that Leonard has never had a birthday party, she and the rest of the guys plan a surprise party for him.
- After a bad breakup, Penny finally agrees to go out on a date with Leonard, however they both develop doubts and turn to Sheldon for advice.
- When Howard hooks up with Penny's old friend, his absence in the gang causes problems for the rest of the guys.
- Tug's space show becomes a space western. Segments include Fozzie's chicken joke, the evil Frogon aliens turning Pigs in Space into toads, Gonzo's airplane catching, Dr. Bunsen's gravity neutralizer, and P.I. Kermit's King Kong case.
- 2007–201921mTV-PG7.6 (4.2K)TV EpisodeLeonard tries to slow down his relationship with Stephanie when he realizes that they are living together, while Sheldon becomes convinced that he has an untraceable disease.
- 2007–201921mTV-PG9.1 (7.1K)TV EpisodeLeonard is disappointed when Penny develops an interest in an attractive physicist at the university. Meanwhile, Sheldon struggles to find an appropriate Christmas gift for Penny.
- 2007–201921mTV-PG7.8 (4.3K)TV EpisodeHoward becomes depressed after Penny makes a cruel statement about his love life, while the rest of the guys prepare for a grudge killer robot duel against an obnoxious colleague at the university.