The Vitruvian Theory is a family-based drama that follows the Vickers family through a series of Thanksgiving dinners. The granddaughter, Lucy, guides the audience back and forth through time to gain insight into the sudden and untimely death of her Aunt Diane. As she watches her family interact throughout the years, she begins to uncover strange circumstances and vindictive relationships. Through burnt turkeys and uncomfortable conversations, she discovers unsettling things about her grandfather, Bill, as she suspects him of knowing more about her Aunt's death than he lets on. As she knows that Thanksgiving day comes and goes, she soon finds that for her family, so does murder.