This episode marks the only on-screen appearance of Duke's, Martin's favorite bar. In later episodes, Martin eventually finds a new hangout at McGinty's.
The scene card "Where Nobody Knows Their Names" is a reference to "Where Everybody Knows Your Name," the theme song of the TV show "Cheers," in which the Frasier Crane character is first introduced. (The song was composed by Gary Portnoy and Judy Hart Angelo in 1982.)
This episode is another example of a large set (Duke's) taking up extra space In the studio other than the usual home, office or cafe. This forces scenes at Nervosa to be shot strictly in the small back area by the bookshelves. The previous episode, "Flour Child", had to do the same thing to accommodate the hospital sets.
Daphne, who's own family consists of eleven seriously dysfunctional members, scolds Niles and Frasier that she never knew a family that worked so hard at being unhappy together.
When Martin goes to introduce Frasier and Niles to Duke, he grabs one of the other patrons instead of Niles by mistake. It's not clear if this was intentional or not as the moment is not played for laughs; the actor who plays him quickly swaps places with David Hyde Pierce and the scene continues.