Ellis Ward mentions that holograms give him a headache, a reference to Robert Duncan McNeill's character Tom Paris' initially difficult relationship with the Doctor (Robert Picardo) in Star Trek: Voyager (1995).
Although this episode shares its title with an episode of The Outer Limits (1963), namely The Human Factor (1963), it is not a remake of that episode and they have no connection beyond the title.
This episode takes place on April 23, 2084.
Like Data (Brent Spiner) in Star Trek: The Next Generation (1987), the android Link has yellow eyes. Spiner previously played Professor Trent Davis in The Deprogrammers (1996).