At least one of the reasons Torres and Kim work on fitting holoprojectors around Voyager in this episode is that the production team of Star Trek: Voyager had, by this point in the series' run, become fed up with The Doctor almost always being confined to sickbay.
The shot of Tuvok miraculously finding himself on Vulcan incorporates a section from a matte painting that was used in Star Trek IV: The Voyage Home (1986) for its background.
This is the last of three episodes that feature Janeway's Gothic holonovel, holosuite program Janeway Lambda one. The holonovel had originally been developed for Eye of the Needle (1995) but was not shown onscreen until Cathexis (1995).
The antagonist here is played by Patrick Kerr, who frequently plays characters on other shows with a serious Star Trek obsession. In fact on the show Frasier (1993) its even stated his character has a restraining order from William Shatner.
"Persistence of Vision" was nominated for an Emmy Award for Outstanding Hairstyling for a Series, along with Our Man Bashir (1995).