Paul has a mystery condition that has caused his face to swell up. While the team try to come up with a diagnosis for Paul, Michael presents them with a second patient. Judy is losing weight as she struggles to swallow food.
The experts are shocked when they read the case notes for 64-year-old army veteran Neil, who has a skin condition so severe it is life-threatening. They are also tasked with helping 35-year-old Kate whose stomach is not emptying properly.
Michael challenges a team of doctors to diagnose a young woman struggling with dramatic weight gain and hair loss and another who has suddenly lost her sight in one eye.
The panel of medical experts try to diagnose a man who is suffering multiple seizures every day and a young woman who has lived with a constant fever for nine years.