In a voiceover, Adult Sheldon says to remember the word Syzygy when playing Scrabble. The image on the screen shows the word spelled using Scrabble tiles, but the game set includes only one Y tile, so the word can't be made as shown. It can only be made using blank tiles.
Sheldon's Scrabble rack, seen 45 seconds into the program, shows the letters SYZYGY. Besides the standard rack having 7 tiles, there are only 2 Ys in the the standard Scrabble set. However, towards the end of a game, players can have have less than 7 tiles in their rack and in the Super Scrabble version of the game there are 4 Ys, so this is a valid possible rack. (This is explained in Chuck Lorre's vanity card at the end of the episode.)
Meemaw isn't scraping anywhere near the Tootsie Roll in the clothes dryer.