Laverne Cox's (Sophia) twin brother, M. Lamar, played her male self before her transition in the flashback sequence.
Deborah Rush, who plays Piper's mother, previously played the mother-in-law-to-be of a character played by Jason Biggs
when she played Michelle's mother in American Wedding (2003).
When Chapman is in Healy's office, he is on eBay looking for another bobble-head like the one that had its head broken off and swallowed by Sophia, to make a point, and so she could go to medical.
This is the first episode that Jodie Foster directs. Foster also directs Looks Blue, Tastes Red (2014)..
Uzo Aduba (Crazy Eyes)'s character was only meant to appear in the first three episodes. After seeing her performances, the writers and producers made her a recurring character.