- Nina & the Proudman clan are shaken by tragedy when a family gathering results in explosive revelations.
- The Proudmans' world is rocked 18 months after the events of the previous chapter of their lives when Cherie reveals that Darcy has died of a heart attack on a cruise. Nina learns that Darcy was in the process of writing a will, and is shocked when she realises that the lawyer, Will is Darcy's son and thus Billie, Jimmy and Ray's half-brother. Billie decides to leave Mick in London and return home for an extended period of time. Zara chooses to put off her medical exam, by using Darcy's death as an excuse. Geraldine fights with her old friend after learning the truth about Will and tries to sleep with Phil D'Arabont. Leo announces that he's seeing someone and a new doctor arrives. Lawrence and his partner Maddy welcome their first child which Nina delivers.
- Eighteen months on from where season five left off, Nina has been in a relationship with dedicated midwife and colleague Leo. Billie has been managing husband Mick's tour in the UK and youngest sibling Jimmy runs his busy Mexican taqueria while his wife Zara undertakes the gruelling challenge of studying for a medical degree. This season Nina must manage a whole new onslaught of mishaps and revelations, as well as unprecedented professional and personal trials that will see the Proudman clan tested as never before. When a tragedy brings the family back together, the stability of life unravels, forcing them once again to question what they thought they knew about themselves and the past - and changing the dynamics of the family forever.
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