When Holby is stretched to breaking point, an angry Ric can't take the status quo any longer. Can Frieda suppress her pain by throwing herself into her work schedule?
Can Ange convince her patient to proceed with a life-saving operation? A resolute Ric campaigns for change. Does Nicky have the strength to fight for what she wants?
Zosia returns to Holby, while a frustrated Jac tries to track down Frieda. Ange admits there is no hope for her patient Holly, but will her parents agree?
Zosia's big news gets a mixed response, and her situation is further complicated when a colleague from the US turns up. Sasha is rattled when an old flame appears on the ward.
A computer virus shuts down Holby's power. Jac and Connie fight to save the lives of close friends. As the hospital is evacuated, Ric mounts a desperate rescue for a trapped Essie.
Ric battles to control Kofi's anger when he arrives at Holby with Darla. Frieda returns to Darwin ready to lose herself in work, only to be paired with a Zosia for the day.
Fletch worries there may be more to Theo's disappearance than meets the eye. Donna meets Xavier's mother for the first time, but things don't go as smoothly as expected.
Ange uncovers a long-buried secret that threatens to completely shatter her world. Can Frieda manage to work within the rules when a friend of Roman's appears in Holby?
Dom throws himself into work as he struggles to process a shocking family secret. Zosia undermines Jac's authority and puts a strain on their already fraught relationship.
A startling incident forces Zosia to reconsider her future at Holby, Cameron has to treat a close relative of Xavier's, and Dom tries to keep Carole at arm's length.
Kian's big personality begin to grate on Jac. Ange opens up to Dom, revealing a big secret about Chloe. When Sue makes a big mistake, Donna tries to limit the damage.
Will Lofty and Dom's marriage survive under the pressure of Isaac's presence at Holby? Is Sacha's relationship with Patricia over before it has even begun? Let us see what happens.
Isaac continues to manipulate Dominic and Lofty as his father's condition worsens. Henrik is shocked when his daughter-in-law and grandson arrive and Chloe attempt to impress Jac but learns her family's business is all around the hospital.
Donna tries to shelter Xavier from his mother's erratic behaviour. Sacha makes a romantic gesture but finds something unexpected in Patricia's cleaning cupboard.
Xavier tries to build bridges with Donna, Cameron can't quite shift his feelings of unease around Evan, and Fletch is anxious about his first official date with Ange.
Evan is stabbed by a patient but uses the opportunity to get closer to Chloe. A mysterious woman turns up looking for Lofty and Serena is uncomfortable working on a case with Fleur after a night out drinking with her.
As her loved ones continue to worry about her, Chloe learns more about Evan. Cameron wants to get out from under Bernie's shadow, but he receives some devastating news.
When Jac is forced to make a career changing decision will life on Darwin ever be the same? And as Serena's tough facade slowly unravels, is grief catching up with her?
Is Chloe brave enough to tell Evan she wants a divorce? And faced with choosing between work and his personal life, will Hanssen learn from past mistakes?
Max performs dangerous brain surgery on Ric, who must confront his own mortality. Dom is shocked when Helen returns to Holby and Lofty finds out she's pregnant.
It's Halloween and Cameron is haunted by his own ghosts. Jac receives a bombshell from Stacey, and will Dominic overstep the mark when it comes to Lofty's baby?