Troy Landry teaches long-time partner Pickle Wheat the ins and outs of python hunting. Veteran snake hunter Bill Booth and Florida hunter Tes Lee must learn to work as a team if they hope to put a dent in the growing python population.
Pickle must face her fear of big cats as she continues to impress Troy with her natural snake hunting talent. Bill and Tes stumble upon a rumored government testing facility and find all they can handle.
Troy and Pickle hunt a giant python known as the night serpent. Tes convinces Bill to try out anew hunting grounds. Zak and Aaron explore a notorious part of the Everglades. Dusty Crum has an idea to lighten his load.
Troy and Pickle witness how far the pythons have spread. Zak and Aaron take on a new type of beast. Bill and Tes tackle some uninvited guests. Dusty does what he can to prevent an early end to his python season.
Troy and Pickle face a familiar foe. Bill and Tes defend a friend's camp from a slithering invasion. Zak and Aaron's hunt leaves a bad taste in their mouths. Dusty has a plan to work smarter not harder.
Troy and Pickle get a tip about a place called the snake pit from a local. Bill and Tes investigate a rock quarry full of pythons. Dusty has a close call with the supernatural. Zak and Aaron fight to protect the local children.
The battle for the Everglades becomes personal for Troy and Pickle. Bill and Tes venture further north than ever before. Zak and Aaron visit Zak's childhood stomping grounds. Dusty heads to one of his favorite honey holes.
Bruce Mitchell joins the fight with Zak and Aaron. Troy, Pickle, Bill, and Tes team up to help a rancher with a serious problem. Dusty devises a way to light up the night.
Troy and Pickle battle a hyper aggressive breed of python. Bill and Tes try to stay one step ahead of the Army Corps of Engineers. Dusty works on a plan to get the snakes to come to him. Zak and Bruce face off against two foes.
Troy and Pickle mix it up with some locals. Tes puts her skills to the test hunting without her partner Bill. Zak and Bruce return to Viper Alley. Dusty hunts for a legend